In the event of a serious anaphylactic reaction, the patient should be treated appropriately with adrenaline and steroids. Preparation should be made in advance to combat any anaphylactic reaction that may occur after an injection of Synacthen. The patient should therefore be kept under observation during this time. Hypersensitivity reactions tend to occur within 30 minutes of an injection. If local or systemic hypersensitivity reactions occur after the injection (for example, marked redness and pain at the injection site, urticaria, pruritus, flushing, faintness, severe malaise or dyspnoea), Synacthen or other ACTH preparations must be discontinued and should be avoided in the future. Synacthen should only be administered under the supervision of appropriate senior hospital medical staff (e.g. In particular, he should enquire whether the patient has previously experienced adverse reactions to ACTH, Synacthen or other drugs. For more accurate dosing of other ages, standard body surface area tables should be consulted.Д®lderly: There is no evidence to suggest that dosage should be different in the elderly.Д«efore using Synacthen, the doctor should make every effort to find out whether the patient is suffering from, or has a history of, allergic disorders (see Section 4.3 вЂњContra-indicationsвЂќ). Thus for children aged 5 to 7 years, approximately half the adult dose will be adequate. Furthermore, a 3-day test with Synacthen Depot may be used to differentiate between primary and secondary adrenocortical insufficiency.Д¬hildren: An intravenous dose of 250micrograms/1.73m 2 body surface area has been suggested. Where the 30-minute test has yielded inconclusive results, or where it is desired to determine the functional reserve of the adrenal cortex, a 5-hour test can be performed with Synacthen Depot (see separate Summary of Product Characteristics). if the value 30 minutes after injection is >500 nmol/litre (180 micrograms/litre), adrenocortical function is regarded as normal.ДЄll the plasma samples should be stored in a refrigerator until plasma cortisol level estimation. Adrenocortical function can be regarded as normal if the post-injection rise in plasma cortisol concentration increases by 200 nmol/litre (70 micrograms/litre), i.e. The 30-minute Synacthen diagnostic test: This test is based on measurement of the plasma cortisol concentration immediately before and exactly 30 minutes after an intramuscular or intravenous injection of 250 micrograms (1ml) Synacthen. Date of first authorisation/renewal of the authorisationДЄdults: This preparation of Synacthen is intended for administration for diagnostic purposes only as a single intramuscular or intravenous dose it is not to be used for repeated therapeutic administration. 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.

4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents

Synacthen atc4